The endocannabinoid system regulates metabolism

By stimulating key receptors in areas like the digestive tract, the pancreas, liver, and even adipose tissue, the endocannabinoid system has been shown to directly affect a variety of metabolic processes.

Studies suggest, for example, that by stimulating receptors in the digestive tract, endocannabinoids can possibly influence digestion and nutrient uptake. Furthermore, research also shows that the endocannabinoid system can directly influence how nutrients are stored and transported around the body.

A 2016 study showed that the endocannabinoid system is involved in a process known as “fat browning.” There are essentially two kinds of fat stores in your body; white fat, which is linked to higher risks of diabetes and heart disease, and brown fat, which can actually help burn energy and calories. Results of this study suggest that the endocannabinoid system may be a target for treating a variety of metabolic conditions, including obesity and diabetes. They also suggest that the ECS may help promote weight-loss. Moreover, this research confirms that the endocannabinoid system has an important homeostatic role in regulating various metabolic processes.


Krott, L., M., et al. (2016). Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation. Journal of Lipid Research, vol. 57, no. 3, 464–473.