LactoSpore® for major depression with irritable bowel syndrome

B.coagulans MTCC 5856 (LactoSpore®) showed robust efficacy for the treatment of patients experiencing IBS symptoms with major depressive disorder. The improvement in depression and IBS symptoms was statistically significant and clinically meaningful. These findings support B. coagulans MTCC 5856 as an important new treatment option for major depressive disorder in IBS patients.


Majeed, M., K., Nagabhushanam, S., Arumugam, S., Majeed and F., Ali. (2018). Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study, Food & Nutrition Research, vol., 62, iss. 1218.