Specific Benefits of Collagen Type I For Joints and Cartilage

Several in vivo and randomised double-blind placebo-controlled clinical studies have proven multiple benefits that you will not find combined in other joint health supplements.

Collagen can keep joints healthy by:

  • Reducing joint discomfort and stiffness1
  • Acting as a cellular trigger to increase collagen and aggrecan production2
  • Helping to prevent cartilage degeneration and support healthy joints3
  • Uniquely helping to reduce joint inflammation3, a leading cause of joint discomfort

Additional facts highlighted by recent scientific studies:

  • Subjects with the greatest joint deterioration benefited the most from the effects of collagen peptides4,5
  • Healthy athletes with reduced joint discomfort also benefited from collagen peptides when walking, standing or carrying objects6.

As one of the most extensively researched collagen peptides brands available on the market today, collagen’s multiple benefits for joint health are well-documented.

Here are some specific highlights from scientific studies:

Collagen stimulates chondrocytes, boosting the production of type 2 collagen

In an in vitro study2, primary cartilage cells, or chondrocytes, were cultured in the presence of different concentrations of collagen. The purpose was to demonstrate collagen’s ability to induce the production of the key cartilage components, aggrecan and type 2 collagen.

Collagen treatment clearly stimulated the expression of aggrecan and type 2 collagen by the cartilage cells.

Less discomfort and stiffness with collagen

In a randomised, placebo-controlled, double-blind clinical trial1, 94 women aged 40 to 70 with knee joint problems (osteoarthritis classification: 0-III) received 8g of collagen daily for a period of six months.

The WOMAC score (the lower the better) measured joint pain and joint function in daily life, while the Lysholm score (the higher the better) evaluated knee joint function when limping, walking, jumping and stair climbing.

Collagen treatment resulted in a statistically significant reduction of the WOMAC score by 24% linked to a 32% decrease in joint pain and a 44% improvement in stiffness.

Collagen treatment also resulted in a statistically significant increase of the Lysholm score by 7%, which demonstrates the improvements over time.

Protecting cartilage and reducing joint inflammation with collagen

A new in vivo study confirms collagen peptides’ role in supporting joint health by providing clear evidence of collagen’s ability to protect the cartilage and to reduce inflammation in mice3. Reporting a visible reduction of cartilage loss in response to osteoarthritis and injury, the research findings highlight collagen’s ability to preserve cartilage and to stimulate the production of extracellular matrix proteoglycans, which are involved in joint lubrication and cushioning.

A common symptom of joint inflammation is the thickening of the synovial membrane which surrounds the knee. This thickening and the presence of inflammation markers was significantly reduced in the collagen-treated groups. These findings have been presented at international scientific congresses, such as the Annual Meeting of the Orthopaedic Research Society and at the World Congress on Osteoarthritis.


1. Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro FOOD Industry Hi Tech, 25:19-23

2. Rousselot unpublished data, 2011

3. Dar Q.A. et al., 2016, Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 24:S532–S533

4. Moskowitz, R. W., 2000, Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99

5. Benito-Ruiz, P. et al., 2009, A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60(Sup2):99-113

6. Clark, K. L. et al., 2008, 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5):1485-1496